ea0028s8.3 | Small molecules, big effects: the emerging role of microRNAs | SFEBES2012
Tattikota Sudhir
, Rathjen Thomas
, Sury Matthias
, Becker Clinton
, Selbach Matthias
, Poy Matthew
MiR-375 regulates growth and function of the pancreatic beta cell, the source of a multitude of secreted factors into the systemic circulation which facilitate metabolic processes, most notably insulin. Here we provide mass spectrometric analysis addressing the impact of miR-375 on the pancreatic beta cell secretome. Quantitative proteomics detected over 600 proteins released in response to glucose using the murine beta cell line, MIN6. Furthermore, the secretome profiles foll...